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Updated: Dec 7, 2025

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

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在微卫星不稳定的癌症中,重复扩张赋予了WRN依赖性

Niek van Wietmarschen1, Sriram Sridharan1, William J Nathan1,2

  • 1Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.

Nature
|October 1, 2020
PubMed
概括

这种 WRN 螺旋酶保护微卫星不稳定性 (MSI) 癌症免受DNA 破坏. 在MSI细胞中扩展的TA重复会阻碍复制,需要WRN来防止染色体破碎.

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