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Updated: Dec 7, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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自体主导的VCP低形变异损害了PHF-tau的分解

Nabil F Darwich1, Jessica M Phan1, Boram Kim1

  • 1Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.

Science (New York, N.Y.)
|October 2, 2020
PubMed
概括

含瓦洛辛蛋白 (VCP) 的基因突变损害了tau的分解,导致神经纤维结和痴呆症. 这种VCP突变为阿尔茨海默病和相关的病症提供了潜在的治疗标.

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