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疫苗引起的抗体的被动转移可以保护 rhesus macaques 免受SIV感染

Galit Alter¹, Wen-Han Yu¹, Abishek Chandrashekar²

¹Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.

|October 2, 2020

概括

从接种疫苗的中被动转移抗体保护了原始动物免受SIV挑战. 这表明疫苗引起的抗体在非人类灵长类动物中具有保护作用,即使没有病毒中和.

科学领域:

免疫学
疫苗学
灵长类模型

背景情况:

艾滋病毒-1和SIV候选疫苗在中显示部分保护.
通过采用转移产生的疫苗抗体的保护效果在非人类灵长类动物中尚未得到充分证实.

研究的目的:

通过采用转移证明疫苗引起的多克隆抗体在天真的非人类灵长类动物中的保护效果.
评估抗体反应并确定疫苗接种的保护性特征.

主要方法:

30只 rhesus 被接种了 Ad26- SIV Env/ Gag/ Pol 和 SIV Env gp140 蛋白质疫苗.
评估了抗体反应和保护性特征.
纯化的免疫球蛋白G (IgG) 被动转移到原始接受者.

主要成果:

从接种疫苗的中被动转移的IgG对未接种疫苗的接受者提供了对SIVmac251挑战的部分保护.
一种与干扰素路径上调相关的保护性抗体特征.
疫苗引起的抗体的保护效果已被证明,独立于中和.

结论:

疫苗引起的抗病毒抗体可以通过被动转移在非人类灵长类动物模型中提供保护.
这项研究证实了特异性抗体功能在对SIV的保护性免疫力中的作用.
这些发现支持开发基于抗体的HIV/SIV预防策略.

关键词:

在ADCC 没有26 艾滋病毒没有SIV 收养转让抗体系统生物学转录组学疫苗的使用

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