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Updated: May 4, 2026

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta
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Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

Published on: September 12, 2017

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单细胞转录组分析揭示了控制和动脉瘤人类大动脉组织中的动态细胞群和差异性基因表达模式

Yanming Li1,2, Pingping Ren1,2, Ashley Dawson1,2

  • 1Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery (Yanming Li, P.R., A. Dawson, H.G.V., W.A., C.Z., W.L., J.S.C., Y.H.S., S.A.L.), Baylor College of Medicine, Houston, TX.

Circulation
|October 5, 2020
PubMed
概括

这项研究揭示了上升胸前动脉瘤 (ATAA) 组织的细胞和分子变化. 免疫细胞增加和线粒体功能障碍是ATAA的关键特征,ERG被认为对大动脉壁健康至关重要.

关键词:
大动脉动脉瘤,胸部动脉瘤线粒体序列分析,RNA转录调节器 ERG

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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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