用中国草药配方治疗隐形高血压:随机化,安慰剂控制的试验
Dong-Yan Zhang1, Yi-Bang Cheng1, Qian-Hui Guo1
1Centre for Epidemiological Studies and Clinical Trials and Centre for Vascular Evaluations, Shanghai Key Laboratory of Hypertension, National Key Laboratory of Medical Genomics, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China (D.-Y.Z., Y.-B.C., Q.-H.G., X.-L.S., F.-F.W., C.-S.S., Q.-F.H., Y.L., J.-G.W.).
Circulation
|October 6, 2020
概括
一种中国的草药配方 - - 胃酸颗粒有效降低了隐形高血压患者的血压. 与安慰剂相比,这项随机试验发现白天门诊血压显著降低,安全性良好.
科学领域:
- 心血管医学
- 药理学
- 传统中国医学
背景情况:
- 面罩式高血压的特征是正常的办公室血压 (BP),但在办公室外血压升高,与不良心血管结果有关.
- 目前,没有随机对照试验 (RCT) 专门针对掩盖高血压的治疗.
- 这项研究研究了使用中国草药配方的潜在治疗方法.
研究的目的:
- 评价胃肠颗粒用于治疗掩盖高血压的疗效和安全性.
- 评估这种草药配方对受影响患者的血压水平的影响.
主要方法:
- 进行了一项随机,安慰剂对照试验,涉及251名面具高血压患者.
- 参与者每天两次接受胃肠颗粒或安慰剂,持续4周.
- 主要疗效终点是白天出院血压的变化.
主要成果:
- 与安慰剂组的2. 91/ 1. 60 mm Hg相比,食用胃豆粒组的白天心/ 腹血压显著降低5. 44/ 3. 39 mm Hg.
- 在白天和24小时门诊血压下降的群体间差异具有统计学意义.
- 治疗耐受性良好,仅报告了一次不良反应 (白天嗜睡),没有严重的不良反应.
结论:
- 对于被诊断患有掩盖性高血压的患者,使用胃酸粒降低血压的治疗是有效的.
- 这种中国传统药物在治疗隐形高血压方面表现出良好的疗效和安全性.
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