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一个桃体电路在探索过程中调解经验依赖的瞬间停顿
Paolo Botta1, Akira Fushiki1, Ana Mafalda Vicente1
1Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Cell
|October 8, 2020
概括
动物学会在熟悉的地方停下来. 一个特定的神经元组合在底侧桃体驱动这些经验依赖的停顿, 揭示了学习行为暂停的电路.
科学领域:
- 神经科学
- 行为生物学
- 计算神经科学
背景情况:
- 探索对于生存和适应至关重要.
- 包括停顿在内的探索行为是经验动态调节的.
- 神经回路必须整合过去的经验来指导未来的行动.
研究的目的:
- 研究在空间探索过程中依赖于经验的行为停止的神经机制.
- 确定特定的大脑区域和神经元群体参与学习暂停.
- 阐明过去经验如何影响正在进行的探索行为.
主要方法:
- 在小鼠中进行空间探索测试.
- 在自由探索过程中对神经元活动的体内成像.
- 已识别的神经元组合的闭环光遗传操纵.
- 投影特定的电路跟踪和操纵.
主要成果:
- 动物在之前访问的地点出现了更多的暂时停留.
- 一个基因定义的神经元组合在底侧桃体 (BLA) 活跃在自我节奏停顿.
- 这个BLA组合显示了经验依赖的招聘.
- 光遗传激活和抑制证实了这些神经元在驱动学习停止过程中的充分性和必要性.
- 发射到中枢桃体的BLA神经元被确定为调解这些停止的关键电路.
结论:
- 基本侧桃体包含一个循环, 调解学习, 经验依赖的暂时停留在探索.
- 这种电路使得动物在熟悉的地方停顿, 而不会引起回避或焦虑的行为.
- 这一发现揭示了一条涉及整合空间记忆与持续探索决策的新杏仁体路径.
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