刺激性肠综合征
Alexander C Ford1, Ami D Sperber2, Maura Corsetti3
1Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK; Leeds Gastroenterology Institute, St James's University Hospital, Leeds, UK.
Lancet (London, England)
|October 13, 2020
概括
刺激性肠综合征 (IBS) 是一种常见的功能性胃肠疾病,其特征是腹痛和改变肠道习惯. 了解肠-大脑轴的病理生理学有助于开发有针对性的治疗方法以改善患者的结果.
科学领域:
- 胃肠病学
- 神经胃肠病学
- 功能性胃肠疾病
背景情况:
- 刺激性肠综合征 (IBS) 影响5-10%的健康人群,表现为腹痛和便形式/频率的变化.
- 风险因素包括肠道感染,心理并发症和年轻女性更高的患病率.
- 病理生理学涉及肠-大脑轴功能障碍,导致运动问题,内脏过敏和中枢神经系统处理变化.
研究的目的:
- 审查当前对刺激性肠综合征 (IBS) 病理生理学的理解.
- 概述IBS的诊断方法和管理策略.
- 突显IBS新型治疗方法的不断发展.
主要方法:
- 对IBS病理生理学,诊断和治疗的现有文献进行审查.
- 风险因素和流行病学数据的分析.
- 检查当前和新兴的治疗干预措施.
主要成果:
- 诊断IBS依赖于临床病史,并对警报症状进行明智的调查.
- 管理重点是患者教育,饮食修改,纤维和抗药.
- 通过神经调节剂,受体特异性药物和心理治疗,
结论:
- 有效的IBS管理需要一个同情的方法,改善生活质量和降低医疗费用.
- 肠-大脑轴是IBS病理生理学的核心,正在进行的研究产生了新的药物候选物.
- 根据最近的病理生理学见解,预计会有越来越多的新型IBS疗法.
相关概念视频
01:17Irritable Bowel Syndrome I: Introduction
755
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
755
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
574
01:30Irritable Bowel Syndrome III: Medical and Nursing Management
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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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01:17Chronic Bowel Disorders: Introduction
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
663
01:17Drugs for Treatment of Diarrhea-Predominant IBS
479
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
479
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
664