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Updated: Dec 5, 2025

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人体内源性BAF复合体的结构模型为疾病机制提供信息

Nazar Mashtalir1, Hiroshi Suzuki2, Daniel P Farrell3

  • 1Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Cell
|October 14, 2020
PubMed
概括

研究人员揭示了与核细胞结合的人类BAF复合体的结构,详细说明了它如何重塑染色体. 这种对BAF复合体 (BRG1/BRM相关因子) 的结构洞察力有助于理解其在健康和疾病中的作用.

关键词:
依赖ATP的染色体重塑BAF复合物癌症交联式质谱学低温电子显微镜同类模型哺乳动物SWI/SNF复合物突变

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