Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.1K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Spatial Orchestration of Skin Fibrosis by a CD8+ T cell-Myofibroblast Axis.

bioRxiv : the preprint server for biology·2026
Same author

Resveratrol Attenuates Obesity by Inducing GDF15 Expression via the p38-ATF3 Signaling Pathway.

Food science & nutrition·2026
Same author

Pediatric Brain Tumor Consortium phase 1 study of CD40 agonist sotigalimab in pediatric and young adult patients with recurrent CNS tumors and newly-diagnosed DIPG.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Association of artificial sweeteners intake and risk of CKD: a prospective cohort study.

The journal of nutrition, health & aging·2026
Same author

Neighborhood social vulnerability and depression prevalence in the United States.

American journal of community psychology·2026
Same author

Nonlinear association of methylmalonic acid with chronic obstructive pulmonary disease and the mediating role of systemic inflammation: A population-based study.

Respiratory medicine·2026
Same journal

Incoming US science academy chief vows to 'double down' on research.

Nature·2026
Same journal

Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

Nature·2026
Same journal

Electrodeposited self-assembled molecules for perovskite photovoltaics.

Nature·2026
Same journal

Neutrino's nursery found: the 'Shadow Blaster'.

Nature·2026
Same journal

Dementia risk in middle-aged people linked to a blood protein.

Nature·2026
Same journal

Daily briefing: What's really happening with trust in science.

Nature·2026
查看所有相关文章

相关实验视频

Updated: Dec 5, 2025

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

4.2K

发育中的人类皮层中的细胞类型特定的3D表观基因组

Michael Song1,2, Mark-Phillip Pebworth3,4, Xiaoyu Yang1

  • 1Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.

Nature
|October 15, 2020
PubMed
概括
此摘要是机器生成的。

这项研究绘制了人类发育中的细胞类型特异性基因调控图,揭示了染色质相互作用如何微调基因表达以确定血统. 一种新的CRISPRview技术在复杂的细胞混合物中验证了这些调节元素.

更多相关视频

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

7.8K
Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function
07:13

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function

Published on: November 29, 2024

1.7K

相关实验视频

Last Updated: Dec 5, 2025

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

4.2K
Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

7.8K
Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function
07:13

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function

Published on: November 29, 2024

1.7K

科学领域:

  • 神经科学
  • 基因组学
  • 发育生物学

背景情况:

  • 由于样本有限和组织复杂性,研究人类皮质生成具有挑战性.
  • 之前的研究已经在发育中的皮质中发现了许多细胞类型和亚型.

研究的目的:

  • 描述人类皮层中细胞类型特异性的表观遗传特征.
  • 研究基因调节和谱系规范中的cis调节性染色体相互作用的作用.
  • 开发一种用于验证初级细胞中的调控元素的新方法.

主要方法:

  • 从怀孕中期的人类皮层中分离特定细胞类型 (放射性细胞,原生细胞,神经元).
  • 细胞类型特异性染色体相互作用,开放染色体和转录体的分析.
  • 开发和应用CRISPRview用于验证cis-regulatory元素.

主要成果:

  • 染色体相互作用对基因调节至关重要,具有可移植元素和疾病变异的特定丰富性.
  • 显示高染色体互动性的超互动性促进体与特定基因相关.
  • 在异构的原始细胞群中,CRISPRview成功验证了细胞类型特定的 cis- 调控元素.

结论:

  • 表观基因组变化,特别是染色体相互作用,在人类皮质生成和谱系规范中起着关键作用.
  • 这些发现提供了关于人类大脑发育过程中的细胞类型特异性基因表达的见解.
  • CRISPRview为研究复杂初级细胞系统中的基因调节提供了强大的工具.