毛细血管细胞类型的专业化
Astrid Gillich1,2,3, Fan Zhang3, Colleen G Farmer4
1Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.
Nature
|October 15, 2020
概括
哺乳动物的肺部
科学领域:
- 肺部生物学和细胞生物学
- 血管和心血管研究
- 进化生物学
背景情况:
- 气膜毛细血管形成气体交换的关键空气-血液屏障.
- 之前的理解假定一个均的毛细血管内皮.
- 膜毛细管网络中的细胞多样性和功能尚未被探索.
研究的目的:
- 通过单细胞分析识别膜毛细体内不同的细胞类型.
- 研究这些专门的内皮细胞的发育,更新和进化起源.
- 了解内皮细胞在肺部健康和疾病中的功能影响.
主要方法:
- 单细胞RNA测序和空间转录组学
- 跨物种的比较分析 (老鼠,人类,鱼,乌).
- 在现场杂交和免疫光染色.
主要成果:
- 发现了两种不同的膜毛细体内皮细胞类型:气球细胞和一般毛细体 (gCap) 细胞.
- 气体细胞专门用于气体交换和白细胞贩运,
- GCAP细胞调节血管运动度,并作为毛细血管修复的干细胞/原始细胞.
- 细胞类型的专业化逐渐发展,在哺乳动物中保存,在爬行动物中缺席,这表明哺乳动物的起源.
- 这些细胞类型对衰老和疾病的反应不同.
结论:
- 膜毛细血管是异质的,由专门的气球细胞和 gCap 细胞组成.
- 这种细胞专业化对于气血屏障功能,平衡和修复至关重要.
- 这些发现揭示了哺乳动物肺血管的关键进化适应.
更多相关视频
09:27Multicellular Human Alveolar Model Composed of Epithelial Cells and Primary Immune Cells for Hazard Assessment
Published on: May 6, 2020
11.7K
10:30Author Spotlight: Developing a Microfluidic Lung-on-Chip Model for In-Depth Study of Human Immune Response and Infection Mechanisms
Published on: May 31, 2024
1.9K
相关概念视频
Alveoli and Alveolar Ducts
4.8K
The respiratory zone of the human body, which stands in contrast to the conducting zone, comprises the structures that actively participate in the exchange of gases. The initiation of this zone is marked by the terminal bronchioles converging into respiratory bronchioles, the tiniest bronchiole classification. The respiratory bronchioles give way to the alveolar ducts that opens into a congregation of alveoli. Actively involved in gas exchange, alveoli resemble tiny sacs similar to clusters of...
4.8K
Capillaries and Their Types
6.8K
Capillaries, a crucial constituent of the circulatory system, are diminutive vessels with a diameter between 5–10 micrometers, accommodating perfusion to the tissues through the phenomenon known as microcirculation. Through their permeable walls, consisting of an endothelial layer ensconced by a basement membrane and sporadically dispersed smooth muscle fibers, the exchange of substances between the blood and the interstitial fluid becomes plausible. Variance in wall composition exists,...
6.8K
Venules
2.4K
Venules are an integral part of the microscopic circulatory system that bridges the gap between capillaries and veins.
Venules are much smaller in diameter compared to their larger counterparts, the veins. They are generally 8 to 100 micrometers in diameter, significantly smaller than the size of veins. The walls of venules are thin, consisting of the endothelium, a thin layer of connective tissue, and occasionally a few smooth muscle cells. This structural simplicity is a stark contrast...
Venules are much smaller in diameter compared to their larger counterparts, the veins. They are generally 8 to 100 micrometers in diameter, significantly smaller than the size of veins. The walls of venules are thin, consisting of the endothelium, a thin layer of connective tissue, and occasionally a few smooth muscle cells. This structural simplicity is a stark contrast...
2.4K
Microvilli
8.3K
Microvilli are tiny finger-like projections found on the surface of certain cells. Their purpose is to increase the surface area of the cell's apical surface, resulting in more effective absorption or secretion of substances.
These microvilli are predominantly present in cells lining the small intestine, kidney tubules, and certain cells in the respiratory and reproductive systems. By significantly expanding the surface area of the cell membrane, microvilli enhance the cell's capacity...
These microvilli are predominantly present in cells lining the small intestine, kidney tubules, and certain cells in the respiratory and reproductive systems. By significantly expanding the surface area of the cell membrane, microvilli enhance the cell's capacity...
8.3K
Capillary Beds
6.1K
Capillary beds are networks of tiny blood vessels that play a crucial role in the circulatory system. These beds are where the exchange of gases, nutrients, and waste products occurs between the blood and surrounding tissues. Each capillary bed consists of numerous capillaries, which are the smallest blood vessels in the body, typically only one cell-thick. This thinness allows for the efficient diffusion of substances.
Capillaries connect arterioles, small branches of arteries, to venules,...
Capillaries connect arterioles, small branches of arteries, to venules,...
6.1K
Diversity of Protists II
657
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
657
