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相关概念视频

The Nucleus01:25

The Nucleus

6.9K
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
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The Nucleus01:32

The Nucleus

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The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
99.2K
Additional Subnuclear Structures02:10

Additional Subnuclear Structures

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The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
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Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
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Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

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Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
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相关实验视频

Updated: Dec 5, 2025

Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers
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Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers

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细胞核测量细胞自身感应的形状变化,以控制细胞的动态行为

Valeria Venturini1,2, Fabio Pezzano2, Frederic Català Castro1

  • 1ICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels, Spain.

Science (New York, N.Y.)
|October 16, 2020
PubMed
概括
此摘要是机器生成的。

细胞使用它们的核作为物理尺度来感知形状的变化和机械压力. 这种细胞自身感应使细胞行为适应周围的微环境,控制迁移和收缩性.

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Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation
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Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

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相关实验视频

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科学领域:

  • 细胞生物学
  • 机械生物学
  • 发育生物学

背景情况:

  • 细胞微环境极大地影响组织发育和平衡.
  • 了解细胞如何感知和响应形状和机械压力等物理线索至关重要.

研究的目的:

  • 研究单个细胞在组织内的机械应力下如何解码几何形状信息.
  • 确定空间感知和适应的细胞机制.

主要方法:

  • 使用斑马鱼模型系统.
  • 研究核作为机械传感器的作用.
  • 分析了内部核膜动力学和依赖的途径.

主要成果:

  • 核作为弹性变形仪,测量细胞形状的变化.
  • 在核伸展时展开的内核膜提供了物理形状信息.
  • 这一过程激活了一种依赖的途径,控制了actomyosin的收缩性和细胞迁移的可塑性.

结论:

  • 细胞核是细胞自身感知的一个关键组成部分.
  • 细胞通过感知细胞核的形状变化来适应它们的行为.
  • 这种机制对于维持组织平衡和发育至关重要.