综合性代谢表型确定年轻人的心血管风险
Venkatesh L Murthy1, Jared P Reis2, Alexander R Pico3
1Departments of Medicine and Radiology, University of Michigan, Ann Arbor (V.L.M.).
Circulation
|October 19, 2020
概括
年轻成年人的代谢特征预测了几十年后心血管疾病 (CVD) 的风险. 这些代谢特征可以识别早期的心脏病路径,并有助于预防风险分层.
科学领域:
- 代谢学
- 心血管疾病研究
- 精准医学
背景情况:
- 心血管疾病 (CVD) 风险通常在40岁以上的个人中进行评估,但早期的CVD病变要早得多.
- 尽管新陈代谢在心血管疾病发展中的作用,但年轻的双种族人群中精确的代谢风险表型仍未得到研究.
研究的目的:
- 确定与不良心血管疾病 (CVD) 表型和长期结果相关的年轻成人的代谢物概况.
- 在独立的队列中探索潜在的机制并验证基于代谢物的风险得分.
主要方法:
- 使用统计学习和考克斯回归方法对2330名年轻成年人进行分析.
- 在Framingham心脏研究中开发和验证基于代谢物的风险得分.
主要成果:
- 成年早期的代谢特征预测了20年内心血管疾病的亚临床发展,揭示了新的心血管疾病途径.
- 两个以代谢物为基础的评分独立与血管和心肌健康相关,与临床心血管疾病相关约25年.
- 这些发现在"弗雷明汉心脏研究"中得到了复制,显示出类似的关联以及心血管疾病风险预测的改善,特别是在年轻人中.
结论:
- 年轻人的新陈代谢标志确定了与心血管疾病相关的新陈代谢功能障碍的关键途径.
- 这些特征与独立群体的长期心血管结果有关.
- 将精确的代谢健康措施纳入风险分层是早期心血管疾病干预的关键.
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