嵌入磁纳米粒子用于MRI和化学热疗的共价有机框架
Farah Benyettou1, Gobinda Das1, Anjana Ramdas Nair1
1New York University Abu Dhabi, P.O. Box 129188, Abu Dhabi, United Arab Emirates.
Journal of the American Chemical Society
|October 22, 2020
概括
研究人员开发了针对癌症治疗的新型磁纳米级共价有机框架 (nCOF). 这些纳米剂提供多克索鲁比,并产生热量用于联合化疗和高热治疗,对质母细胞瘤和斑马鱼胚胎有希望.
科学领域:
- 材料科学
- 纳米技术
- 生物医学工程
背景情况:
- 共价有机框架 (COF) 提供可调节的多孔结构,用于药物输送.
- 磁纳米颗粒可以提供有针对性的传输和成像.
- 结合化疗高温是一种协同治疗癌症的方法.
研究的目的:
- 开发用于同时进行化疗,高温和MRI成像的多功能纳米级共价有机框架 (nCOF).
- 在酸性瘤微环境中设计适应pH的纳米剂.
- 在体外和体内评估开发的纳米剂的疗效和安全性.
主要方法:
- 含多克索鲁比,-Fe2O3纳米颗粒涂层和聚-氨酸稳定 nCOFs (γ-SD/PLL) 的合成.
- 在酸性 (pH 5. 4) 和生理性 (pH 7. 4) 条件下对pH反应药物释放的评估.
- 在质母细胞细胞和斑马鱼胚胎中对交替磁场和细胞毒性测试的热生成的评估.
主要成果:
- γ-SD/PLL纳米剂表现出pH特定的多克索鲁释放,主要是在酸性内体/溶体环境中.
- 在磁场暴露时获得有效的热量产生 (48°C),表明有效的高热潜力.
- 对质母细胞U251-MG细胞和斑马鱼胚胎观察到协同性细胞毒性,对非癌性HEK293细胞的毒性最小.
结论:
- 开发的磁性nCOF复合材料作为有效的多模式MRI探针和化疗热疗剂.
- 具有pH反应的药物释放和磁性过热提供了有针对性和协同作用的癌症治疗策略.
- 这项研究为先进的癌症治疗提供了一个新的平台,
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