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Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
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在多发性硬化症中,HLA-DR15分子共同形成自动反应性T细胞谱

Jian Wang1, Ivan Jelcic1, Lena Mühlenbruch2

  • 1Neuroimmunology and MS Research, Neurology Clinic, University Hospital Zurich, University of Zurich, Zurich 8091, Switzerland.

Cell
|October 22, 2020
PubMed
概括

这种HLA-DR15类型是多发性硬化症 (MS) 的主要风险因素,形成自主反应性T细胞. 这项研究揭示了HLA-DR15异构体如何呈现自我和外来抗原,从而导致MS的发病.

关键词:
B 单元格HLA 的交叉限制由HLA-DR衍生的自我HLA-DR15分子T细胞的表现一个T细胞自体免疫性疾病自主反应的CD4+交叉反应性免疫体多发性硬化症

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