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Updated: Dec 4, 2025

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
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Published on: October 23, 2019

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由于抑制C终端Src激酶而导致的易布鲁替尼心房动

Ling Xiao1, Joe-Elie Salem2,3,4, Sebastian Clauss1,5,6

  • 1Cardiovascular Research Center (L.X., S.C., A.H., A.B., J.T., M.N., P.T.E., D.J.M.), Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Circulation
|October 23, 2020
PubMed
概括

易布鲁替尼通过抑制C端Src激酶 (CSK) 引起心房动,这是一种非目标效应. 这一发现解释了这种B细胞癌症药物的关键副作用.

关键词:
人类BTK蛋白CSK 氨酸蛋白激酶心房动电生理学艾布鲁替尼蛋白质激酶抑制剂

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