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相关概念视频

Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

2.0K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
2.0K
Overview of Somatic Sensory Pathways01:29

Overview of Somatic Sensory Pathways

7.7K
Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
7.7K
Somatosensation01:33

Somatosensation

42.5K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
42.5K
Spinal Cord: Information Processing01:10

Spinal Cord: Information Processing

2.6K
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
2.6K
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

3.5K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
3.5K
Sympathetic Pathways: Sympathetic Chain Ganglia01:20

Sympathetic Pathways: Sympathetic Chain Ganglia

4.8K
The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.The postganglionic neurons of the sympathetic trunk...
4.8K

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相关实验视频

Updated: Dec 3, 2025

Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans
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Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans

Published on: March 15, 2019

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平行上升的脊柱通道用于情感触摸和疼痛

Seungwon Choi1, Junichi Hachisuka2,3,4, Matthew A Brett1

  • 1Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.

Nature
|October 29, 2020
PubMed
概括

通过TACR1和GPR83表达识别的两个不同的脊髓投射神经元群,形成疼痛和触觉信号的并行通路. 这些通路在感官处理和情感行为中发挥着不同的作用.

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Recording Network Activity in Spinal Nociceptive Circuits Using Microelectrode Arrays
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相关实验视频

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Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans
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科学领域:

  • 神经科学
  • 感官生物学
  • 疼痛研究

背景情况:

  • 从脊髓传递疼痛,温度和触摸信号到大脑.
  • 对于开发有效的疼痛治疗方法至关重要.
  • 这条途径中的投射神经元是关键的治疗点.

研究的目的:

  • 阐明两侧通道的组织逻辑.
  • 识别不同的神经元群体及其在感官处理中的作用.
  • 研究这些途径对触摸和疼痛的情感方面的贡献.

主要方法:

  • 标识表达TACR1和GPR83的投射神经元群.
  • 追踪脊神经元 (SPB) 投射到侧神经核.
  • 对SPB神经元轴突终端的光遗传刺激.
  • 对SPB神经元刺激反应的电生理记录.

主要成果:

  • 确定了两个平行上升电路模块,表达TACR1和GPR83.
  • 这些模块传递热,触觉和有害的皮肤信号.
  • 表达GPR83的SPB神经元对机械刺激敏感,并表现出强度依赖的价值.
  • 在刺激时观察到明显的亚核内化和行为反应.

结论:

  • 前侧途由基于TACR1和GPR83表达的单独的SPB神经元分组组成.
  • 这些细分体具有独特的解剖学,生理学和功能性质.
  • 这些发现揭示了触觉和疼痛感知的神经基础.