肠道神经元在繁殖过程中增加母亲的食物摄入量
Dafni Hadjieconomou1,2, George King1,2, Pedro Gaspar1,2
1MRC London Institute of Medical Sciences, London, UK.
Nature
|October 29, 2020
概括
雌性昆虫在繁殖过程中增加食物摄入量. 这项研究确定了果中特定的肠道神经元来调节这种繁殖过敏,将神经元可塑性与繁殖成功联系起来.
科学领域:
- 神经生物学
- 生殖生物学
- 昆虫生理学
背景情况:
- 在许多雌性动物中,繁殖需要增加能量摄入量.
- 在繁殖过程中对食欲的调节对母亲的健康和后代的发展至关重要.
- 神经系统的作用,特别是肠道内接,在调解生殖养方面尚未完全理解.
研究的目的:
- 研究Drosophila melanogaster在繁殖过程中增加食物摄入量的肠道神经元的作用.
- 确定肠道中性别和生殖状态特定的神经元活动的分子和细胞机制.
- 确定肠道神经元可塑性对生殖过敏和整体生殖能力的影响.
主要方法:
- 对雌果肠道神经元多样性和活动的分析.
- 研究类固醇和肠内分泌激素对肠道神经元重塑的影响.
- 检查肠道神经元释放的神经对作物肌肉功能和养行为的影响.
- 评估肠道神经元可塑性的改变对生殖功能过敏和健康的影响.
主要成果:
- 鉴定特定的肠内激活神经元,其活动模式随性和生殖状态而变化.
- 证明类固醇和内分泌荷尔蒙在交配后功能性地重塑这些神经元.
- 这些神经元释放的神经会改变作物动态,增加食物摄入量.
- 干扰肠道神经元重塑会损害生殖功能,并降低生殖能力.
结论:
- 肠道神经元的可塑性对于维持繁殖所需的增加食物摄入量 (繁殖过) 是必不可少的.
- 一个涉及肠道神经元,荷尔蒙和神经的特定神经回路调节生殖胃口.
- 这种机制确保了孕期和繁殖成功所必需的正能量平衡.
- 这种系统的失调可能会导致不孕或体重增加.
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