当肠道微生物入脂肪时,脂肪就会回来
Sean P Spencer1, Justin L Sonnenburg2
1Division of Gastroenterology and Hepatology, Stanford School of Medicine, Stanford, CA, USA; Microbiology & Immunology, Stanford School of Medicine, Stanford, CA, USA.
Cell
|October 30, 2020
概括
研究人员在介质脂肪组织 (MAT) 中发现了各种微生物, 挑战了以前的假设. 这些肠道细菌有助于克罗恩病的"爬行脂肪"特征.
科学领域:
- 微生物学
- 胃肠病学
- 免疫学
背景情况:
- 肠道微生物群对肠道健康起着至关重要的作用.
- 中肠脂肪组织 (MAT) 围绕着胃肠道,其在住宿微生物中的作用尚不清楚.
研究的目的:
- 为了研究中介质脂肪组织 (MAT) 中的微生物多样性.
- 了解这些微生物对克罗恩病的致病作用, 特别是"爬行脂肪".
主要方法:
- 介质脂肪组织样本的微生物分析.
- 细菌物种及其代谢适应的识别.
主要成果:
- 在MAT中发现了前所未有的活力微生物多样性.
- 证据表明这些微生物来自肠道微生物群.
- 这些细菌在代谢上适应了MAT环境.
结论:
- 这里有各种各样的微生物群落.
- 在MAT中错位和适应的肠道细菌有助于克罗恩病中观察到的"爬行脂肪".
相关概念视频
Anatomy of the Intestines
85.9K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
85.9K
Bacterial Flora of the Large Intestine
1.0K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.0K
What is Monogastric Digestion?
74.4K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
74.4K
Lipid Absorption
2.1K
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
2.1K
Lipid Digestion
97.6K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
97.6K
Hypodermis
7.0K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
7.0K


