培养颗粒形成的先天免疫能促进抗瘤活性
Lydia Kalafati1, Ioannis Kourtzelis2, Jonas Schulte-Schrepping3
1Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany; National Center for Tumor Diseases, Partner Site Dresden, 01307 Dresden and German Cancer Research Center, Heidelberg, 69120 Heidelberg, Germany.
由β- 葡萄糖诱导的训练免疫通过重编程中性粒细胞来增强抗瘤反应. 这种免疫训练有效地减少了瘤的生长,
科学领域:
- 免疫学
- 癌症研究
- 天生的免疫力
背景情况:
- 训练有素的天生的免疫力提高了对次要挑战的反应.
- 在抗瘤策略中训练免疫的潜力在很大程度上尚未被探索.
- 调节髓状细胞或原始细胞可以诱导训练免疫力.
研究的目的:
- 调查是否可以诱导训练免疫来增强抗瘤免疫力.
- 探索β-葡萄糖诱导的抗瘤作用的机制.
- 在癌症中确定训练免疫的治疗潜力.
主要方法:
- 小鼠接受了训练有素的免疫激动剂β- 葡萄糖的预治疗.
- 对骨髓细胞进行了转录和表观遗传分析.
- 中性粒细胞通过收养转移,并监测瘤的生长.
- 使用骨髓移植来评估传染性.
主要成果:
- 在小鼠中,β- 葡萄糖预治疗减少了瘤的生长.
- 经过训练的免疫包括颗粒形成和中性粒细胞重编程的表观遗传和转录组连接.
- 独立于适应性免疫,I型干扰素信号对抗瘤效果至关重要.
- 从受过训练的小鼠中移植的中性粒细胞通过活性氧物种 (ROS) 抑制了瘤的生长.
- 通过骨髓移植可以传播抗瘤作用.
结论:
- 由β-葡萄糖诱导的训练免疫力显示出一种新的抗瘤作用.
- 颗粒形成和中性粒细胞的重编程是一个关键机制.
- 这种方法为增强抗瘤免疫提供了治疗相关的策略.
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