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  11. 非洲裔美国人种族与积极监测治疗低风险前列腺癌的男性的临床结果之间的联系

非洲裔美国人种族与积极监测治疗低风险前列腺癌的男性的临床结果之间的联系

Rishi Deka1,2, P Travis Courtney1,2, J Kellogg Parsons1,3

  • 1VHA San Diego Health Care System, La Jolla, California.

JAMA
|November 3, 2020

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在PubMed 上查看摘要

概括
此摘要是机器生成的。

与非西班牙裔白人男性相比,患前列腺癌风险较低的非洲裔美国男性的疾病进展和治疗率更高. 然而,不同组的转移和前列腺癌特异性死亡率相似.

科学领域:

  • 癌症学
  • 泌尿外科
  • 健康上的差异

背景情况:

  • 与非西班牙裔白人男性相比,非洲裔美国男性患前列腺癌的可能性更大.
  • 作为患有低风险前列腺癌的非裔美国男性的治疗策略,积极监测的适用性仍然不确定.

研究的目的:

  • 为了比较非裔美国人和非西班牙裔白人男性的临床结果,他们被诊断患有低风险的前列腺癌,并接受积极监测.

主要方法:

  • 使用美国退伍军人卫生管理卫生保健系统的数据进行了回顾性队列研究.
  • 该研究包括2001年至2015年期间被诊断患有低风险前列腺癌的非裔美国人和非西班牙裔白人男性,并进行积极监测.
  • 评估结果包括疾病进展,接受终极治疗,转移,前列腺癌特异性死亡率和全因死亡率.

主要成果:

  • 这项研究包括8726名男性 (26. 1% 非洲裔美国人, 73. 9% 非西班牙裔白人),随访时间中位数为7. 6年.
  • 与非西班牙裔白人男性相比,非洲裔美国男性的10年累计发病率 (59.9% vs 48.3%) 和最终治疗率 (54.8% vs 41.4%) 显著增加.
  • 在两组之间没有观察到转移发病率 (1.5%与1. 4%) 或前列腺癌特异性死亡率 (1. 1%与1. 0%) 的统计学意义上的差异.

结论:

  • 与非西班牙裔白人男性相比,在积极监测下患前列腺癌风险较低的非洲裔男性的疾病进展率和最终治疗率更高.
  • 在这个队列中,非裔美国人和非西班牙裔白人男性的转移和前列腺癌特异性死亡率相似.
  • 需要进行进一步的长期跟踪,以充分评估与积极监测相关的死亡风险.

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