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在人体细胞中识别SARS-CoV-2感染所需的宿主因子

Zharko Daniloski1, Tristan X Jordan2, Hans-Hermann Wessels1

  • 1New York Genome Center, New York, NY, USA; Department of Biology, New York University, New York, NY, USA.

Cell
|November 4, 2020
PubMed
概括

这项研究使用CRISPR查确定了SARS-CoV-2感染的重要宿主基因. 发现这些宿主因素揭示了COVID-19治疗的新治疗目标.

关键词:
美国关于CRISPR的研究其他国家其他国家冠状病毒胆固醇细胞内核全基因组选人类肺部功能丧失

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Coronavirus01:29

Coronavirus

Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...