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Updated: Dec 2, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Published on: February 20, 2018

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GPCR异形的组合表达影响信号和药物反应

Maria Marti-Solano1, Stephanie E Crilly2, Duccio Malinverni3,4

  • 1MRC Laboratory of Molecular Biology, Cambridge, UK. mmarti@mrc-lmb.cam.ac.uk.

Nature
|November 5, 2020
PubMed
概括

G蛋白结合受体 (GPCR) 产生具有独特信号特性的多种功能性异构体. 这些异构体在组织中的组合表达会产生不同的信号状态,影响药物反应并提供新的治疗点.

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