在人体中对SARS-CoV-2的既有和新发性免疫力
Kevin W Ng1, Nikhil Faulkner1, Georgina H Cornish1
1Retroviral Immunology, The Francis Crick Institute, London NW1 1AT, UK.
概括
在未感染的个体中检测到对SARS-CoV-2的存在免疫力,特别是在儿童中. 这种先前存在的幽默免疫,主要是针对S2亚单元的IgG,表现出中和活性,影响对新冠病毒的敏感性.
科学领域:
- 免疫学
- 病毒学
- 传染性疾病
背景情况:
- 动物感染的冠状病毒可以遇到先前存在的人类免疫力.
- 了解这种免疫力对于评估易感性和疾病进展至关重要.
研究的目的:
- 在未感染个体中检测和表征已存在的针对SARS-CoV-2的幽默免疫力.
- 区分先前存在的免疫与由感染引起的新免疫.
主要方法:
- 利用多种抗体测试,包括流细胞计,检测针对SARS-CoV-2蛋白质的抗体.
- 分析的抗体类别 (IgG,IgM,IgA) 和基蛋白的目标亚单元 (S1,S2).
- 评估未感染者血清对SARS-CoV-2和伪型的中和活性.
主要成果:
- 在未感染个体,特别是儿童和青少年中发现了先前存在的SARS-CoV-2尖端糖蛋白 (S) 反应抗体.
- 这些抗体主要是针对S2亚单元的免疫球蛋白G (IgG).
- 感染SARS-CoV-2导致对S1和S2的IgG标位更高,以及对IgM和IgA的持续免疫力.
结论:
- 已经存在的针对SARS-CoV-2的幽默免疫力存在,并且可以表现出中和作用.
- 在了解SARS-CoV-2的流行病学和发病过程中,区分先前存在的免疫和感染引起的免疫是至关重要的.
相关概念视频
Humoral Immune Responses
81.3K
Overview
81.3K
Immunological Memory
14.4K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
14.4K
Development of Immunocompetence
601
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
601
Vaccinations
49.7K
Overview
49.7K
Active versus Passive Immunity
9.4K
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Active Immunity
Active immunity refers to the resistance one develops...
9.4K
Antigens Involved in Adaptive Immunity
986
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
986


