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在K18-hACE2小鼠中的COVID-19治疗和病原体

Jian Zheng¹, Lok-Yin Roy Wong¹, Kun Li²

¹Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.

|November 9, 2020

概括

在K18-hACE2小鼠中,严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 感染会导致肺部和大脑疾病,康复性血可以防止致命的结果. 这种模型有助于COVID-19研究.

科学领域:

病毒学
免疫学
病理学

背景情况:

由SARS-CoV-2引起的COVID-19流行病具有显著的发病率和死亡率.
需要进一步调查COVID-19病变的关键方面,包括呼吸系统症状较小的厌氧症.
动物模型对于研究人类患者难以评估的疾病方面至关重要.

研究的目的:

使用K18-hACE2转基因小鼠调查COVID-19的病理基础.
在SARS-CoV-2感染模型中评估康复期血的治疗潜力.
探索SARS-CoV-2感染的小鼠中厌氧症的发展.

主要方法:

感染K18-hACE2转基因小鼠的SARS-CoV-2.
评估肺部和大脑疾病的严重程度.
对血栓形成和血管炎进行组织病理学检查.
用康复期血作为治疗干预措施.
监测化病的发生情况.

主要成果:

在K18-hACE2小鼠中,SARS-CoV-2感染引发了严重的肺部疾病,在某些情况下,大脑也受到影响.
在患有严重肺炎的小鼠中观察到血栓形成和血管炎的证据.
康复期的血输注可以预防致命的疾病.
感染后的早期出现了无氧化症,并没有通过康复性血治疗来预防.
K18-hACE2小鼠表现出从轻度到致命的COVID-19严重程度的范围.

结论:

K18-hACE2小鼠作为研究轻度和致命性COVID-19的有价值模型.
这种模型对于评估康复期血等治疗干预措施的有效性是有效的.
该模型强调了严重的COVID-19中神经干预和血栓形成的可能性.
需要进一步的研究来了解和解决SARS-CoV-2诱导的厌氧症.

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