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Updated: Nov 30, 2025

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
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Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

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通过mTORC1-USP20-HMGCR轴诱导胆固醇的生物合成

Xiao-Yi Lu1, Xiong-Jie Shi1, Ao Hu1

  • 1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Frontier Science Center for Immunology and Metabolism, the Institute for Advanced Studies, Wuhan University, Wuhan, China.

Nature
|November 12, 2020
PubMed
概括

由mTORC1调节的双化酶USP20在养后稳定胆固醇合成酶HMGCR. 抑制USP20可以减少体重增加,改善新陈代谢健康,提供新的治疗点.

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