与阿洛普里诺尔相比,费布可斯塔特在痛风患者中的长期心血管安全性 (FAST):多中心,前性,随机化,开放性,非劣势性试验
在PubMed上查看摘要
概括
此摘要是机器生成的。对于痛风患者来说,费布克斯塔特与阿洛普林醇一样安全,心血管安全性不差. 长期使用febuxostat (一种尿酸降低疗法) 与allopurinol相比没有增加死亡或严重不良事件的风险.
科学领域
- 心血管医学
- 关节病学
- 临床药理学
背景情况
- 由于担心甲状腺炎的尿酸降低疗法fbuxostat的心血管安全性,因此进行了比较研究.
- 欧洲药物管理局建议评估febuxostat与allopurinol的心血管安全性.
研究的目的
- 在患有痛风的患者中进行非劣势性试验,比较febuxostat与allopurinol的心血管安全性.
- 评估两种尿酸降低疗法的长期结果,包括心血管事件和死亡率.
主要方法
- 一个前性,随机的,开放的,盲目的终点试验,涉及超过6000名60岁以上的患有心血管风险因素的痛风患者.
- 患者被指派继续使用优化氨酸或转换为氨酸,心血管事件作为主要复合终点.
- 使用心肌梗塞,急性冠状动脉综合征,中风或心血管死亡的综合分析评估了非劣势.
主要成果
- 在初级心血管终点 (调整HR为0. 85;95%CI为0. 70-1. 03) 方面,费布克苏塔特的效果与阿洛普里诺不相差.
- 发病率每100个患者年为1. 72的费布克苏斯塔特和2. 05的阿洛普里诺.
- 长期安全性是可比的,与素相比,素不增加死亡或严重不良事件的风险.
结论
- 在痛风患者中,费布古斯塔特的心血管安全性与阿洛普林醇相比并非劣.
- 与阿洛普林醇相比,长期使用费布克苏塔特并没有增加死亡或严重不良事件的风险.
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