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Antigen Presenting Cells01:22

Antigen Presenting Cells

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
2.5K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.2K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.2K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

80.6K
Overview
80.6K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

7.5K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
7.5K
Tumor Immunotherapy01:27

Tumor Immunotherapy

955
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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T Cell Types and Functions01:24

T Cell Types and Functions

1.8K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.8K

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相关实验视频

Updated: Nov 30, 2025

Artificial Antigen Presenting Cell aAPC Mediated Activation and Expansion of Natural Killer T Cells
13:18

Artificial Antigen Presenting Cell aAPC Mediated Activation and Expansion of Natural Killer T Cells

Published on: December 29, 2012

18.5K

快照:APC/T细胞免疫检查点

Scott H Shrager1, Christina Kiel1

  • 1Systems Biology Ireland and UCD Charles Institute of Dermatology, School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.

Cell
|November 13, 2020
PubMed
概括

免疫检查点调节自我耐受性和免疫反应. 通过调节T细胞活动来治疗自身免疫性疾病和癌症.

科学领域:

  • 免疫学
  • 细胞生物学
  • 癌症研究

背景情况:

  • 免疫检查点对于维持自我耐受性和控制免疫反应至关重要.
  • 免疫检查点的失调与自身免疫性疾病和癌症有关.
  • 针对免疫检查点已经成为成功的治疗策略.

研究的目的:

  • 为了说明免疫检查点的相互作用.
  • 专注于抗原呈现细胞 (APC) 介导的T细胞调节.
  • 提供这些互动的视觉概述 (快照).

主要方法:

  • 对免疫检查点的现有文献进行审查和综合.
  • 关注涉及抗原呈现细胞 (APC) 的相互作用.
  • 对T细胞调节通路的视觉表示.

主要成果:

  • 已知免疫检查点相互作用的详细说明.
  • 强调APC在调节T细胞反应中的作用.
  • 确定T细胞激活和抑制的关键调节点.

结论:

  • 免疫检查点是免疫反应的重要调节者.

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Killer Artificial Antigen Presenting Cells KaAPC for Efficient In Vitro Depletion of Human Antigen-specific T Cells
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Killer Artificial Antigen Presenting Cells KaAPC for Efficient In Vitro Depletion of Human Antigen-specific T Cells

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Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation
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Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation

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相关实验视频

Last Updated: Nov 30, 2025

Artificial Antigen Presenting Cell aAPC Mediated Activation and Expansion of Natural Killer T Cells
13:18

Artificial Antigen Presenting Cell aAPC Mediated Activation and Expansion of Natural Killer T Cells

Published on: December 29, 2012

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Killer Artificial Antigen Presenting Cells KaAPC for Efficient In Vitro Depletion of Human Antigen-specific T Cells
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Killer Artificial Antigen Presenting Cells KaAPC for Efficient In Vitro Depletion of Human Antigen-specific T Cells

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Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation
10:16

Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation

Published on: October 12, 2018

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  • 以APC为媒介的T细胞调节是治疗干预的关键领域.
  • 了解这些相互作用对于开发癌症和自身免疫疾病的新疗法至关重要.