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膀癌:一个回顾
Andrew T Lenis1, Patrick M Lec1, Karim Chamie
1Institute of Urologic Oncology (IUO), Department of Urology, David Geffen School of Medicine, University of California, Los Angeles.
JAMA
|November 17, 2020
概括
膀癌的诊断和治疗已经有了很大的进步. 包括免疫疗法和向药物在内的新疗法为肌肉侵袭性和晚期膀癌提供了超越传统治疗方法的选择,比如菌卡尔梅特-盖林 (BCG).
科学领域:
- 癌症学
- 尿道病学
背景情况:
- 膀癌是一种常见的恶性瘤,从非侵袭性到侵袭性形式.
- 危险因素包括年龄,男性性别和吸烟.
- 瘤存在血,需要通过囊镜和成像进行评估.
研究的目的:
- 审查膀癌的诊断和治疗情况.
- 突出治疗非肌肉侵袭性,肌肉侵袭性和晚期膀癌的进展.
主要方法:
- 审查目前的诊断方式,包括增强的囊镜.
- 讨论不同阶段的膀癌的治疗策略.
- 探索新兴疗法,如免疫疗法和向药物.
主要成果:
- 对于中等/高风险的非肌肉侵入性膀癌,肠道 Calmette-Guérin (BCG) 仍然是标准.
- 增强型囊镜可以更好地检测瘤,并可能减少瘤复发.
- 肌肉侵袭性和晚期疾病的治疗已经显著扩大.
结论:
- 在膀癌的诊断和治疗方面,
- 免疫疗法,向疗法和抗体药物结合剂对于晚期疾病至关重要.
- 膀癌的治疗方案不断扩大,
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