巨型病毒的广泛内源化塑造了绿藻的基因组
Mohammad Moniruzzaman1, Alaina R Weinheimer1, Carolina A Martinez-Gutierrez1
1Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA.
Nature
|November 19, 2020
概括
来自核细胞质大DNA病毒 (NCLDV) 的巨大内源性病毒元素 (EVE) 已被发现集成到绿藻基因组中. 这些巨大的病毒序列显著扩大了真核生物中已知的病毒基因规模.
科学领域:
- 基因组学
- 进化生物学
- 病毒学
背景情况:
- 内源性病毒元素 (EVE) 是在真核生物中普遍存在的综合病毒基因组,在基因组进化中起着关键作用.
- 大多数确定的EVE都是小的,但大型双链DNA病毒也可能内源化.
- 核细胞质大型DNA病毒 (NCLDV) 由于其庞大的基因组和复杂的起源而引起人们的兴趣,但其作为EVE的作用尚不清楚.
研究的目的:
- 在真核生物基因组中研究NCLDV内源化的流行和特征.
- 确定NCLDV是否对真核基因组内的病毒基因规模有显著的贡献.
主要方法:
- 对绿藻基因组进行分析以识别集成的病毒序列.
- 确定内源性NCLDV的大小,基因含量和基因组特征的特征.
- 对基因组进行比较分析,以评估与宿主基因组的基因共享和同化.
主要成果:
- 在各种绿藻中发现了NCLDV的广泛内源化.
- 这些巨大的EVE超过100万个基因对, 包含高达10%的主机开放的读取框架.
- 内源化元素显示同化证据,包括共享的基因,内核和重复.
结论:
- 在真核生物中,NCLDVs是大量内源性病毒元素的重要来源.
- NCLDVs的内源化大大增加了真核基因组中的病毒基因规模.
- 这一过程作为新型遗传物质的导体,影响了真核生物的基因组组成和进化.
相关概念视频
Green Algae
477
Green algae, also referred to as chlorophytes, are different from red algae in having the chloroplasts containing chlorophylls a and b, which give them their distinct green hue. However, they lack phycobiliproteins, preventing them from developing the red or blue-green pigmentation seen in red algae. In terms of photosynthetic pigment composition, green algae closely resemble plants and share a close evolutionary relationship with them. Taxonomically Green algae belong to Phylum Chlorophyta in...
477
Red Algae
541
Red algae, also known as rhodophytes, are primarily found in marine environments, though some species inhabit freshwater and terrestrial ecosystems. These organisms exist in both unicellular and multicellular forms, with some multicellular varieties reaching macroscopic sizes.As phototrophic organisms, red algae contain chlorophyll a; however, their chloroplasts lack chlorophyll b. Instead, they possess phycobiliproteins, which serve as major light-harvesting pigments, similar to those found in...
541
Viruses of Archaea
308
Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...
308
Diversity of Protists I
657
Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
657
Overview of Algae
540
The kingdom Archaeplastida encompasses red and green algae, along with land plants. Unlike other protists with chloroplasts that arose through secondary endosymbiosis, only red and green algae originated from primary endosymbiotic events. This diverse group of eukaryotic organisms contains chlorophyll and performs oxygenic photosynthesis.Algae exist in various forms, from large brown kelp in coastal waters to green scum in puddles and stains on rocks or soil. Some species are responsible for...
540
Size and Structure of Viral Genomes
462
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
462


