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Updated: Nov 29, 2025

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

在移植中氧化与标准冷 perfusion 保存 (COMPARE):一个随机,双盲,配对的第三阶段试验

Ina Jochmans¹, Aukje Brat², Lucy Davies³

¹Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium; Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium.

Lancet (London, England)

|November 22, 2020

概括

在低温机器输液 (HMPO2) 过程中补充氧气对于循环死亡的捐赠者的脏是安全的. 虽然HMPO2没有显著改善12个月的eGFR,但它减少了严重的并发症和移植失败.

科学领域:

科和移植手术
器官保存和输血技术

背景情况:

保存通常涉及寒冷,低毒的条件,可能导致保存损伤.
保存期间的氧化可能会减轻损伤,特别是在风险较高的脏.
这项研究评估了氧气在循环死亡捐赠者的脏低温机器 (HMP) 中的作用.

研究的目的:

确定在低温机器输液 (HMPO2) 期间补充氧气是否会改善循环死亡后捐赠脏的结果.
与标准HMP相比,评估氧化HMP的安全性和有效性.

主要方法:

一个随机,双盲,配对的第三阶段试验涉及19个欧洲移植中心.
从50岁以上的捐赠者捐赠的脏对被分配到HMPO2或标准HMP中.
主要结局:估计12个月球过率 (eGFR);次要结局:严重并发症和移植失败.

主要成果:

在HMPO2 (50. 5毫升/ 分/ 1. 73m2) 和HMP (46. 7毫升/ 分/ 1. 73m2) 组之间,12个月的eGFR没有显著差异 (p=0. 12).
HMPO2组的严重并发症显著减少 (11%对16%,p=0. 032).
在HMPO2组中,移植失败明显较低 (3%对10%,p=0. 028).

结论:

氧化低温机器输液 (HMPO2) 在循环死亡后捐赠的脏是安全的.
HMPO2显著减少了严重的移植后并发症和移植失败.
虽然HMPO2在初级eGFR终点上没有达到统计意义,但它显示出有前途的好处.

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