青少年和成年人的神经认知功能障碍和较小的大脑体积
Charlotte E Verrall1,2, Joseph Y M Yang3,4, Jian Chen4
1Heart Centre for Children (C.E.V., J.A., D.S.W.), The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Circulation
|November 24, 2020
概括
神经认知障碍在Fontan循环患者中很常见,对成年人影响更大. 较小的大脑体积和白质损伤与较差的认知功能有关, 这凸显了解决大脑损伤因素的必要性.
科学领域:
- 心脏病学
- 神经科学
- 儿童健康
背景情况:
- 青少年和成年人的神经认知结果尚不清楚.
- 丰丹循环对长期的神经健康构成独特的挑战.
- 了解童年后的神经认知功能对于这一群体至关重要.
研究的目的:
- 研究青少年和成年人的神经认知功能.
- 探索神经认知结果与结构性脑损伤,脑体积和临床因素之间的关联.
- 将Fontan患者的神经认知功能与对照组进行比较.
主要方法:
- 一项双国研究招募了107名具有Fontan循环的参与者.
- 使用Cogstate软件评估神经认知功能.
- 用体积分析进行脑MRI,并与对照组和数据库进行比较.
主要成果:
- 与对照组相比,Fontan循环的参与者表现出更差的神经认知功能.
- 较差的结果与更多的住院时间,手术年龄较小以及手术后的时间较长有关.
- 观察到全球和区域大脑体积较小,与神经认知缺陷相关.
结论:
- 在青少年和成年人中,神经认知障碍很常见.
- 这种损伤与大脑灰白质量减少有关.
- 确定可修改的因素来优化神经认知功能是必不可少的.
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