肝脏的共生驱动免疫区域促进宿主防御
Anita Gola1,2, Michael G Dorrington3, Emily Speranza4,5
1Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. agola@rockefeller.edu.
Nature
|November 26, 2020
概括
肝脏
科学领域:
- 免疫学
- 肝病学
- 微生物学
背景情况:
- 肝脏的免疫细胞被认为是均分布的,与淋巴体器官不同.
- 这与肝脏的血流不对称,
研究的目的:
- 研究肝叶内免疫细胞的空间分布.
- 确定免疫细胞局部化与对肠道病原体的宿主保护之间的关系.
主要方法:
- 定量多重成像
- 遗传性疾病
- 转录组学
- 基于感染的测定
- 数学模型
主要成果:
- 常驻的髓状和淋巴状免疫细胞集中在肝脏的周门区域.
- 这种不对称的免疫细胞分布是由肠道微生物群影响的肝侧内皮细胞中MYD88依赖的信号传递驱动的.
- 与均分布相比,免疫细胞的空间两极化增强了对全身细菌传播的保护.
结论:
- 根据微生物组的感知,肝侧内皮细胞积极协调免疫细胞的局部化.
- 这种活跃的免疫细胞组织优化了肝脏对肠道病原体的防御.
相关概念视频
Secondary Lymphoid Organs
8.3K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
8.3K
Functions of the Lymphatic and Immune System
5.4K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
5.4K
Immune Response Against Viral Pathogens
1.3K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.3K
Cell-mediated Immune Responses
80.5K
Overview
80.5K
B Cell Activation and Differentiation
15.4K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
15.4K
Introduction to Lymphatic and Immune System
15.4K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
15.4K


