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相关概念视频

Solving Problems in Physics02:32

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Problem-solving is the ability to apply general physical principles to specific situations, usually expressed by equations. It is an essential skill in physics, and can also be useful for applying physics in everyday life as well. Analytical skills and problem-solving abilities can be applied to new situations, compared to a list of facts, which can never be extensive enough to include every possible circumstance. To solve physics problems, a certain amount of creativity and insight is...
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The Scope of Physics01:17

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Physics is concerned with the interactions of energy, matter, space, and time, in order to discover the underlying mechanisms that underpin all phenomena. The word "physics" comes from the Greek word "phúsis", which means nature. Physics seeks to comprehend the natural world around us at its most fundamental level. It emphasizes the use of quantitative laws to do this, which could be valuable in other fields that want to push the performance boundaries of present...
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Kinematic Equations: Problem Solving01:15

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When analyzing one-dimensional motion with constant acceleration, the problem-solving strategy involves identifying the known quantities and choosing the appropriate kinematic equations to solve for the unknowns. Either one or two kinematic equations are needed to solve for the unknowns, depending on the known and unknown quantities. Generally, the number of equations required is the same as the number of unknown quantities in the given example. Two-body pursuit problems always require two...
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Imagine a solid object involved in a general planar movement, with its center of mass pinpointed at a spot labeled G. The object's kinetic energy relative to an arbitrary point A can be quantified for each of its particles - the ith particle in this case. This measurement is achieved through the employment of the relative velocity definition. The position vector, known as rA, extends from point A to the mass element i.
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Newton's First Law: Introduction01:17

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Motion draws our attention. Motion itself can be beautiful, causing us to marvel at the forces needed to create spectacular sights, such as that of a dolphin jumping out of the water, the flight of a bird, or the orbit of a satellite. The study of motion is kinematics, but kinematics only describes the way objects move—their velocity and acceleration. Dynamics considers the forces that affect the motion of moving objects and systems. Newton's laws of motion are the foundation of...
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Kinetic Energy00:23

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Kinetic energy is the ability of an object in motion to do work or enact change. It can take on many forms. For instance, water flowing down a waterfall has kinetic energy. In biological systems, particles of light travel and are absorbed by plants to create chemical energy. Animals consume the chemical energy and give off molecules that carry their scent through the air. They also generate kinetic energy when they run away from predators. Entire systems also possess kinetic energy, like the...
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相关实验视频

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Electron Cryotomography of Bacterial Cells
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通过物理学讲述蛋白质故事

Emiliano Brini1, Carlos Simmerling1,2, Ken Dill3,2,4

  • 1Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794, USA.

Science (New York, N.Y.)
|November 27, 2020
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概括

计算分子物理 (CMP) 正在彻底改变我们对蛋白质行为的理解. 这种方法使用物理原理来揭示详细的蛋白质动力学,推动生物发现.

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科学领域:

  • 生物物理
  • 计算生物学
  • 结构生物学

背景情况:

  • 蛋白质具有复杂的生物作用,包括折叠,结合和功能.
  • 蛋白质结构通常用于了解蛋白质的行为.
  • 了解蛋白质动态对于理解生物过程和疾病至关重要.

研究的目的:

  • 突出计算分子物理 (CMP) 在解读蛋白质行为的不断增长的作用.
  • 解释CMP如何提供对蛋白质结构动态的细粒度见解.
  • 展示CMP的最新进展,使其能够研究更大的生物系统和更长的时间尺度.

主要方法:

  • 使用物理原理来模拟蛋白质的行为.
  • 在空间和时间上分析形态群体.
  • 使用先进的计算技术来模拟蛋白质的动态.

主要成果:

  • CMP揭示了有关蛋白质折叠,结合和生物作用的详细信息.
  • 最近的进展允许研究更长的时间尺度和更大的分子系统.
  • 盲目测试验证了CMP在理解蛋白质行为的预测能力.

结论:

  • 计算分子物理对于讲述蛋白质的"故事"越来越重要.
  • CMP提供了强大的基于物理的方法来补充传统的结构生物学.
  • CMP的持续进步有望在原子层面释放更深层次的生物学见解.