大麻素和Δ9-四大麻素对驾驶表现的影响:随机临床试验
Thomas R Arkell1,2,3,4, Frederick Vinckenbosch4, Richard C Kevin1,2,5
1Lambert Initiative for Cannabinoid Therapeutics, The University of Sydney, Sydney, New South Wales, Australia.
JAMA
|December 1, 2020
概括
大麻主要含有四大麻 (THC) 显著影响驾驶,而大麻主要含有大麻 (CBD) 则似乎没有影响驾驶性能. 需要进一步研究以了解混合THC和CBD大麻对驾驶安全的影响.
科学领域:
- 神经科学
- 药理学
- 法医科学
背景情况:
- 大麻使用与车祸风险增加有关.
- 大麻醇 (CBD) 对驾驶障碍的具体影响尚不清楚.
研究的目的:
- 评估含有Δ9-四大麻 (THC) 和CBD的蒸发大麻造成的驾驶障碍.
主要方法:
- 这是一项双盲随机临床试验,
- 参与者蒸发了THC主导,CBD主导或THC/CBD等效的大麻 (13.75毫克剂量) 或安慰剂.
- 在40分钟和240分钟后的道路测试中,通过横向位置的标准偏差 (SDLP) 评估驾驶性能.
主要成果:
- 与安慰剂相比,THC 主导和THC/CBD 相当的大麻在服用后40至100分钟显著增加SDLP.
- 在任何一个时间点中,CBD主导的大麻都没有显著改变SDLP.
- 在所有大麻类型中,驾驶障碍的影响在消费后减少了240-300分钟.
结论:
- 蒸发的THC,特别是在THC主导或同等配方中,会在短期内降低驾驶性能.
- 在这项研究中,CBD主导的大麻没有显著的驾驶障碍.
- 这些发现表明THC是大麻相关驾驶障碍的主要驱动因素,但CBD的微妙障碍的可能性不能完全排除,常见的使用模式可能与研究剂量不同.
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