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基斯H3.3G34-突变性内部神经元原始体对质生成的 PDGFRA

Carol C L Chen1, Shriya Deshmukh2, Selin Jessa3

  • 1Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada.

Cell
|December 1, 2020
PubMed
概括

具有Histone H3.3 G34R/V突变的致命质瘤来自内部神经元原生细胞,而不是质细胞. 这些突变损害了分化和合作PDGFRA信号,推动瘤生长.

关键词:
一个GSX2H3.3 G34R/V 其他美国细胞的起源染色体形状质瘤内部神经元原始体在基上儿童癌症单细胞转录组

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