在出生时激活的脑干系统保护出生后的呼吸
Yingtang Shi1, Daniel S Stornetta1, Robert J Reklow2
1Department of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Nature
|December 3, 2020
概括
一个新发现的神经系统,垂体腺酸环酶激活多 (PACAP),对于启动新生儿呼吸至关重要. 这种系统在出生后立即支持呼吸功能, 帮助过渡到子宫外生命.
科学领域:
- 神经科学
- 呼吸系统生理学
- 发育生物学
背景情况:
- 在早期发育过程中, 呼吸的调节是脆弱的.
- 支持第一个呼吸的神经机制尚未完全理解.
- 过渡到子宫外的生命带来了重要的呼吸挑战.
研究的目的:
- 在出生时确定调节呼吸的神经系统.
- 研究神经在新生儿呼吸控制中的作用.
- 为了阐明出生后呼吸调整的分子机制.
主要方法:
- 使用了缺乏特定神经系统的转基因小鼠.
- 研究了垂体腺酸环酶激活多 (PACAP) 在逆核 (RTN) 神经元中的功能.
- 研究了PACAP及其受体 (PAC1) 对呼吸活动和CO2刺激的影响.
主要成果:
- 在RTN神经元中缺乏PACAP的小鼠表现出增加的呼吸暂停和减少的CO2刺激呼吸.
- 在Bötzinger前综合体中删除PACAP受体PAC1模仿了这些呼吸缺陷.
- 在出生时观察到RTN神经元中PACAP表达的特异性产后激增,与环境暴露相关.
结论:
- 在RTN神经元中适当的PACAP表达提供了出生后的基本呼吸驱动.
- PACAP通过其在Bötzinger前综合体中的受体PAC1起作用,以支持呼吸.
- 这种体神经回路对于新生儿脆弱时期的呼吸稳定至关重要.
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