含有α-螺旋式疏水块的两聚对自组的溶剂作用
Avanashiappan Nandakumar1, Yoshihiro Ito1,2, Motoki Ueda1,2
1Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science (CEMS), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Journal of the American Chemical Society
|December 4, 2020
概括
乙醇和酸通过改变水结构影响的自我组合. 乙醇增强了疏水性相互作用,而乙烯则稳定了组件,模仿了生物材料中的溶解效应.
科学领域:
- 生物材料科学
- 超分子化学
- 软物质物理学
背景情况:
- 生物分子的自我组合是理解代谢事件的关键.
- 溶剂可以通过加强水的键网络来稳定蛋白质的原生状态.
- 确定生物模拟自组合的有效辅溶剂是一项挑战.
研究的目的:
- 调查乙醇 (EtOH) 和乙二 (ACN) 对水溶液中的两性多PSar30-{l-Leu-Aib) 6 (S30L12) 的自组合的影响.
- 观察形态变化并了解共溶剂诱导的自我组装的分子机制.
- 为了比较EtOH和ACN在仿生应用中的作用.
主要方法:
- 传输电子显微镜 (TEM) 用于形态分析.
- 循环二重化 (CD) 光谱和膜流动性测试用于分子包装.
- 福里埃变换红外光谱 (FT-IR) 用于分析生物材料的自组装.
主要成果:
- 乙醇加强了水的键网络,限制了疏水和增强了组件间的疏水相互作用.
- 乙形成纳米集群,稳定组合并加速组合动力学.
- EtOH和ACN都对生物材料的自我组装表现出类似于溶解剂或类似于变质剂的作用.
结论:
- 同溶剂EtOH和ACN显著调节S30L12多的自组.
- EtOH和ACN的独特机制突显了它们在仿生材料设计中的可调剂潜力.
- 通过溶剂工程来控制软材料的自组合.
更多相关视频
05:08Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
17.3K
05:24Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
Published on: September 6, 2024
1.5K
相关概念视频
Solubility
20.3K
Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules,...
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules,...
20.3K
Entropy and Solvation
7.9K
The process of surrounding a solute with solvent is called solvation. It involves evenly distributing the solute within the solvent. The rule of thumb for determining a solvent for a given compound is that like dissolves like. A good solvent has molecular characteristics similar to those of the compound to be dissolved. For example, polar solutions dissolve polar solutes, and apolar solvents dissolve apolar solutes. A polar solvent is a solvent that has a high dielectric constant (ϵ...
7.9K
Solvating Effects
8.2K
An understanding of the solvating effect helps rationalize the relation between solvation and acidity of the compound. In addition, this also explains the relative stability of conjugate bases for compounds with different pKa values. This lesson details, in-depth, the principle of solvating effects. The strength of an acid and the stability of its corresponding conjugate base are determined using pKa values. This observed relationship is a consequence of solvation, which is the interaction...
8.2K
Intermolecular Forces
66.8K
Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen...
66.8K
