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相关概念视频

Bipolar Disorder01:30

Bipolar Disorder

420
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
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Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

434
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
434
Borderline Personality Disorder01:25

Borderline Personality Disorder

321
Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
321
Personality Disorders: Paranoid and Schizoid01:22

Personality Disorders: Paranoid and Schizoid

325
Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...
325
Personality Disorders: Schizotypal and Histrionic01:20

Personality Disorders: Schizotypal and Histrionic

274
Schizotypal personality disorder and histrionic personality disorder are two distinct psychological conditions classified under personality disorders, each characterized by unique behavioral patterns and social difficulties. Both disorders significantly affect interpersonal relationships and emotional well-being, leading to social isolation and frustration.
Schizotypal Personality Disorder: Eccentric Behavior and Social Withdrawal
Schizotypal personality disorder is marked by odd or eccentric...
274
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

356
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
356

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Updated: Nov 27, 2025

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

954

双极性障碍 双极性障碍 双极性障碍

Roger S McIntyre1, Michael Berk2, Elisa Brietzke3

  • 1Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.

Lancet (London, England)
|December 6, 2020
PubMed
概括

双极性障碍是慢性疾病,严重影响预期寿命和功能. 虽然遗传学起着作用,但环境因素和并发症对于理解和治疗双相情感障碍至关重要.

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科学领域:

  • 精神病学和行为科学
  • 遗传学和基因组学 遗传学和基因组学
  • 神经科学是一个神经科学.

背景情况:

  • 双极性障碍 (BPI,BPII) 是一种严重的,慢性精神健康状况,减少了心理社会功能和预期寿命.
  • 高遗传性 (70%) 将双相情感障碍与其他精神和医疗状况联系起来,与BPI (精神分裂症) 和BPII (严重抑郁症) 有着明显的遗传关联.
  • 病变发生涉及神经细胞质可塑性,单氨基信号传递,炎症,细胞新陈代谢和线粒体功能障碍,受童年虐待的影响.

研究的目的:

  • 为初级保健医生提供对双相情感障碍的诊断,病原遗传和治疗考虑的概述.
  • 综合当前关于双相情感障碍流行病学,机制,查和治疗的证据.
  • 突出解决伴随性疾病和心理社会因素在治疗双相情感障碍中的重要性.

主要方法:

  • 对双相情感障碍现有证据的审查和综合.
  • 对遗传关联,病原遗传途径和环境影响的分析.
  • 评估当前的药理和心理社会治疗策略.

主要成果:

  • 抑郁症发作显著导致双相情感障碍的发病率和死亡率,尽管躁狂症定义了双相情感障碍.
  • 仍然是一个黄金标准的情绪稳定剂;抗精神病药物对躁狂有效,但对双极性抑郁症不一致.
  • 在双相情感障碍中使用抗抑郁药缺乏强有力的疗效证据,可能导致情绪不稳定;全球范围内获得有效治疗的机会有限.

结论:

  • 双相情感障碍的有效管理需要解决医疗和精神病相关疾病,整合心理社会治疗,并涉及护理人员.
  • 初级保健医生在查,诊断和治疗双极性障碍方面发挥着至关重要的作用.
  • 需要进一步的研究来提高治疗的可访问性和有效性,特别是在双极性抑郁症.