巴西亚马逊地区 SARS-CoV-2 发病率的四分之三在大大未减轻的流行期间
Lewis F Buss1, Carlos A Prete2, Claudia M M Abrahim3
1Departamento de Molestias Infecciosas e Parasitarias and Instituto de Medicina Tropical da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
概括
截至2020年10月,巴西马纳乌斯的COVID-19感染率达到76%,表明疫情已大范围蔓延,并未得到缓解. 这种高感染率凸显了2019年新冠肺炎疾病传播控制不良的严重影响.
科学领域:
- 流行病学
- 免疫学
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 在巴西北部的马纳乌斯造成了快速的流行.
- 马纳乌斯的疫情基本上没有得到缓解,
研究的目的:
- 通过血清学数据,估计巴西马纳乌斯的COVID-19感染率.
- 为了比较马纳乌斯和圣保罗的攻击率.
主要方法:
- 为了检测免疫球蛋白G (IgG) 抗体,使用了献血者的便利样本.
- 对于无法检测到的抗体反应和抗体减弱,进行了统计纠正.
主要成果:
- 截至 2020 年 6 月, 44% 的马纳乌斯人口具有可检测的 IgG 抗体.
- 据估计,马纳乌斯的COVID-19感染率在6月份为66%,到10月份增加到76%.
- 据估计,10月份圣保罗的攻击率为29%.
结论:
- 无法控制的COVID-19可以感染相当一部分人口.
- 与圣保罗相比, 马纳乌斯的攻击率明显高.
- 高发作率与显著的死亡率有关.
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