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小鼠胚胎的发育时钟和新两极化机制

Meng Zhu1, Jake Cornwall-Scoones2, Peizhe Wang3

  • 1Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.

Science (New York, N.Y.)
|December 11, 2020
PubMed
概括

鼠标胚胎的两极分化对于发育至关重要,由胚胎基因组激活触发. 转录因子Tfap2c, Tead4和RhoA启动了这一过程,使细胞命运规范和形态发生成为可能.

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Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...