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便微生物移植促进了免疫治疗耐药黑色素瘤患者的反应

Erez N Baruch1,2, Ilan Youngster3,4, Guy Ben-Betzalel5

  • 1The Ella Lemelbaum Institute for Immuno-Oncology, Sheba Medical Center, Tel-HaShomer, Israel. erezbaruch@mail.tau.ac.il gal.markel@sheba.health.gov.il.

Science (New York, N.Y.)
|December 11, 2020
PubMed
概括

在晚期黑色素瘤患者中,便微生物移植 (FMT) 结合抗编程细胞死亡-1 (PD-1) 免疫治疗显示出有前途的结果. 这种方法调节了肠道微生物和免疫反应, 为癌症治疗提供了新的希望.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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