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Updated: Nov 26, 2025

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
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通过可见光介导的光催化剂在DNA中的N6-甲基氨酸残留物中进行选择性化学功能化

Manuel Nappi1, Alexandre Hofer1, Shankar Balasubramanian1,2,3

  • 1Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

Journal of the American Chemical Society
|December 11, 2020
PubMed
概括

研究人员开发了一种新的可见光方法来化学修改N6-甲基腺和脱氧腺, 这种技术允许在DNA和RNA中标记和丰富这些修饰的核酸.

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相关概念视频

Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
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