在青少年和成年人中查乙型肝炎病毒感染:美国预防服务工作组建议声明
, Alex H Krist1,2, Karina W Davidson3
1Fairfax Family Practice Residency, Fairfax, Virginia.
JAMA
|December 15, 2020
概括
建议青少年和成人进行乙型肝炎病毒 (HBV) 感染查. 通过查及早检测可以预防严重的肝病.
科学领域:
- 肝病学
- 传染性疾病
- 预防医学
背景情况:
- 在美国,慢性乙型肝炎病毒 (HBV) 感染约有862,000人.
- 高风险群体包括出生在高发病率地区的人,注射毒品的人,同性恋者和艾滋病毒感染者.
- 许多感染者不知道自己的病情,导致诊断延迟,并可能导致肝硬化或末期肝病.
研究的目的:
- 更新2014年关于乙型肝炎病毒 (HBV) 查的建议.
- 评估查和抗病毒治疗对预防中间和健康结果的益处和危害.
- 评估其他HBV查策略和风险识别工具.
主要方法:
- 从2014年到2019年8月发表的随机临床试验和队列研究的系统审查.
- 专注于查益处,危害和诊断准确性的新证据.
- 包括对替代查策略和风险评估工具的分析.
主要成果:
- 在高危青少年和成年人中检查HBV感染的净益处中等.
- 有证据支持查识别无症状感染的好处.
- 该审查考虑了查策略和风险分层的新数据.
结论:
- 美国预防服务工作组 (USPSTF) 建议在高危人群中对HBV感染进行查.
- 这项建议 (B级) 是基于良好的科学证据提出的建议.
- 查对于早期发现和治疗乙型肝炎至关重要.
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