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相关概念视频

Protein Networks02:26

Protein Networks

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Protein Networks02:26

Protein Networks

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Nucleic acids02:43

Nucleic acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic Acids02:43

Nucleic Acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic Acids02:43

Nucleic Acids

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Nucleic Acid Structure01:25

Nucleic Acid Structure

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
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DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
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基于核酸的结构动态网络:从基本原则到应用

Liang Yue1, Shan Wang1, Zhixin Zhou1

  • 1Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

Journal of the American Chemical Society
|December 16, 2020
PubMed
概括

这项研究引入了模仿自然生物系统的动态化学网络的核酸. 这些网络表现出适应性行为,并在催化和材料科学中具有潜在的应用.

科学领域:

  • 系统化学
  • 超分子化学
  • 化学生物学

背景情况:

  • 大自然利用复杂的DNA,RNA和蛋白质的细胞内网络进行编程反应.
  • 通过化学手段模仿这些自然动态过程是系统化学的一个关键目标.

研究的目的:

  • 引入核酸作为构建立体动态网络 (CDN) 的功能模块.
  • 探索基于核酸的CDN的适应性和响应性.
  • 讨论CDN的潜在应用和未来发展方向.

主要方法:

  • 使用核酸序列作为CDN的构建块.
  • 设计信号触发可重新配置的CDN.
  • 研究CDN系统中的相互通信和反机制.

主要成果:

  • 基于核酸的CDN具有适应性和等级性适应性.
  • 这些网络展示了相互沟通和反驱动的途径.
  • 在编程催化,纳米粒子组装和水凝功能方面显示出潜力.

结论:

  • 核酸为创建复杂,适应性的CDN提供了多功能平台.

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  • CDN是模仿自然系统和开发新功能材料的有希望的方法.
  • 未来的研究包括短暂的CDN,蛋白质合成和人工细胞发展.