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Updated: Nov 25, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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人类线粒体DNA转录的小分子抑制剂

Nina A Bonekamp1, Bradley Peter2, Hauke S Hillen3

  • 1Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, Germany.

Nature
|December 17, 2020
PubMed
概括

科学家开发了针对POLRMT的新型线粒体转录抑制剂 (IMTs). 这些IMT有效地降低了线粒体DNA表达和氧化酸化,在临床前模型中显示出抗瘤作用.

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