高稳定Zr(IV) 基金属有机框架用于逆相液态染色学
Hong Jiang1, Kuiwei Yang2, Xiangxiang Zhao1
1School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, China.
Journal of the American Chemical Society
|December 28, 2020
概括
基于的高稳定性金属有机框架 (MOF) 被引入为反相高性能液态染色学 (RP-HPLC) 的高效性静止相 (CSP). 这些新型MOF在分离各种种族物质,包括氨基酸和药物方面表现出色.
科学领域:
- 材料科学
- 分析化学
- 有机化学
背景情况:
- 在化学和药理学中,奇拉分离至关重要,像MOF这样的多孔材料被探索为奇拉静止相 (CSP).
- 开发有效的反相高性能液态染色学 (RP-HPLC),主要的分离模式,仍然是一个重大挑战.
研究的目的:
- 证明基于的高度稳定的MOF作为RP-HPLC的CSP的有效性.
- 合成和描述具有可调节通道大小的新奇合MOF,以实现立体选择性识别.
主要方法:
- 通过从1,1'-二-20-皇冠-6中衍生出来的四碳酸联体合成三种性多孔Zr(IV) -MOF.
- 对MOF结构,稳定性 (水,酸,耐受性) 和通道性质的描述.
- 在酸性水溶液条件下分离各种赛马体的MOF包装HPLC列的评估.
- 密度函数理论 (DFT) 计算以阐明分离选择性的机制.
主要成果:
- 成功合成了三种具有相同拓但不同通道大小的Zr-MOF,具有高稳定性.
- 在MOF通道中的冠以太部分使客分子的立体选择性识别成为可能.
- 用这些Zr-MOF包装的HPLC列在分离模型赛马中实现了高分辨率,选择性和耐用性.
- 分离性能与RP-HPLC的现有商业合柱相当或优于它.
结论:
- 高稳定的基于Zr的MOF是RP-HPLC的有效和强大的CSP.
- 在MOFs中的受限微环境,由奇拉皇冠以太决定,控制分离的选择性.
- 这些新型MOF为要求严格的染色学应用提供了一个有前途的解决方案.
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