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脑干电路中的各种前肢作用的功能地图
Ludwig Ruder1,2, Riccardo Schina1,2, Harsh Kanodia1,2
1Biozentrum, Department of Cell Biology, University of Basel, Basel, Switzerland.
Nature
|January 7, 2021
概括
研究人员绘制了大脑干电路, 侧面面脊髓 (latRM) 中的特定神经元群控制着伸手和食物处理等行为, 揭示了运动控制的新见解.
科学领域:
- 神经科学
- 发动机控制
- 大脑干电路
背景情况:
- 脑干对于控制身体运动至关重要.
- 了解前肢运动的神经控制是有限的,重点是大脑上部中心和脊髓.
研究的目的:
- 在大脑干的侧面面脊髓 (latRM) 中定义熟练前肢运动的功能地图.
- 确定负责复杂前肢活动的特定神经元群体和电路.
主要方法:
- 在自由移动的小鼠体内电生理学.
- 基因操纵和病毒追踪技术
- 神经元群体的光遗传刺激.
主要成果:
- 在LATRM群体中识别了一个神经元代码,调整到不同的前肢动作 (例如,伸手,处理食物).
- 激发性LATRM神经元的干扰影响了这些作用.
- 激发性RM神经元通过轴突目标分离,差异性地招募脑干和脊柱电路.
- 预测定义的latRM群体的光遗传刺激引起了多样化,稳定的前肢运动.
结论:
- 在latRM中投影分层的大脑干群编码动作阶段.
- 这些群体作为构建块来调节复杂的前肢运动.
- 识别了前肢行为关键的脑干基质.
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