对食物抗原的局部免疫反应导致食用引起的腹痛
Javier Aguilera-Lizarraga1, Morgane V Florens1, Maria Francesca Viola1
1Laboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
Nature
|January 14, 2021
概括
食物引起的胃肠道症状,如腹痛,可能源于引起免疫反应的细菌感染. 这种反应使神经变得敏感,
科学领域:
- 胃肠病学
- 免疫学
- 神经科学
背景情况:
- 食物引起的胃肠道症状影响全球多达20%,影响生活质量和医疗费用.
- 尽管越来越多的兴趣和饮食干预措施, 但这些症状背后的机制尚不清楚.
研究的目的:
- 研究食物引起的腹痛的潜在机制.
- 确定刺激性肠综合征 (IBS) 和相关疾病的潜在治疗点.
主要方法:
- 在细菌感染后诱导小鼠对饮食抗原的免疫反应.
- 对内脏疼痛信号通路的评估.
- 对IBS患者在食物抗原刺激时的瘤细胞激活和局部组织反应的分析.
主要成果:
- 细菌感染和毒素触发了小鼠对饮食抗原的肠特异性IgE抗体的产生.
- 随后的抗原摄入导致IgE和巨细胞依赖的内脏疼痛,通过组胺H1受体介导的敏感化.
- 在IBS患者中,食物抗原诱导局部胀和巨细胞激活.
结论:
- 一个涉及IgE,巨细胞和胰岛素的外围机制调解食物引起的腹痛.
- 这一发现为IBS和其他腹部疼痛症提供了新的治疗途径.
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