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Updated: Nov 20, 2025

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

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在细胞环境中识别多个具有广泛序列耐受性的G-四重体相关蛋白质

Haomiao Su, Jinglei Xu, Yuqi Chen

  • 1Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.

Journal of the American Chemical Society
|January 20, 2021
PubMed
概括

研究人员开发了一种新的体内方法,使用G4联体介导的交叉链接来识别与G四重复 (G4) 相关的蛋白质 (G4RP). 这种方法在细胞中发现了许多G4RPs,进步了生物学中G4功能的研究.

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A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase111:25

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相关概念视频

Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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