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对小鼠视觉系统的研究显示功能层次结构

Joshua H Siegle¹, Xiaoxuan Jia², Séverine Durand³

¹Allen Institute for Brain Science, Seattle, WA, USA. joshs@alleninstitute.org.

|January 21, 2021

概括

这项研究绘制了老鼠视觉系统中的神经活动图, 神经活动和行为相关性在视觉层次上得到加强.

科学领域:

神经科学
系统神经科学
计算神经科学

背景情况:

哺乳动物的视觉系统表现出从视网膜到新皮层的层次结构.
在多个视觉区域同时进行细胞水平的功能记录具有挑战性,限制了对等级相互作用的理解.

研究的目的:

在老鼠视觉层次上提供一个大,开放的神经活动数据集.
在视觉处理过程中调查这个层次结构中的功能连接和编码原则.

主要方法:

在六个皮层和两个脑膜区域的小鼠中调查了成千上万个神经元的激增活动.
使用视觉刺激和交叉相关性分析来绘制区域间的功能连接.
分析了诸如响应延迟,受体场大小和相锁定等等级的指标.

主要成果:

功能连接组织反映了解剖学层次结构.
经典的等级测量 (延迟,受体场大小,相锁定,衰变时间表) 与等级相关.
神经活动与行为选择之间的相关性在视觉层次上增加.

结论:

这些发现为理解神经编码和在等级组织的视觉区域中的信号传播奠定了基础.
开放式数据集促进了对哺乳动物视觉系统的进一步研究.

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相关概念视频

Visual System

Visual System

Light enters the eye through the cornea, a transparent, dome-shaped surface covering the surface of the eyeball that helps to direct and focus incoming light. This light is then channeled toward the pupil, an adjustable opening whose size is controlled by the iris. The iris, a pigmented muscle, regulates the amount of light entering the eye by contracting or dilating the pupil, thereby ensuring optimal light levels for clear vision.
Once through the pupil, the light passes through the lens, a...